Richard J. Martin, BVSc, PhD, DSc, DipECVPT, MRCVS
Professor of Pharmacology, Department of Biomedical Sciences, Iowa State University,
Ames, IA 50011
Richard J. Martin, Alan P. Robertson, S. Verma, Shivani Choudhary, Sudhanva Kashyap, Melanie Abongwa and Fudan Zheng
Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA
We can predict aspects of the future by creating new knowledge. When we look at drugs that are used to control parasites, we see that there is new knowledge about their mode of action and this knowledge is predicted to allow us to put combinations of drugs together more rationally to increase the spectrum of action and to slow the development of anthelmintic resistance. In this paper we comment on some recent observations of ours on the modes of action of emodepside, diethylcarbamazine and tribendimidine. Emodepside increases the activation of a SLO-1 K current inhibiting movement, and diethylcarbamazine has a synergistic effect on the effect of emodepside on the SLO-1 K current, increasing the size of the response. The combination may be considered for further testing for therapeutic use. Tribendimidine is a selective cholinergic nematode B-subtype nAChR agonist, producing muscle depolarization and contraction. It has different subtype selectivity to levamisole and may be effective in the presence of some types of levamisole resistance. The new information about the modes of action may aid the design of rational drug combinations designed to slow the development of resistance or increase the spectrum of action.