Carlos E. Lanusse, argentine, 55 years old, married,
Carlos E. Lanusse received his Veterinary degree from theUniversidad Nacional del Centro de la Pcia. de Buenos Aires (Tandil, Argentina) (1982). He completed a first Doctoral degree at the Universidad Nacional de La Plata (La Plata, Argentina) (1986) and his Ph.D. program atMcGill University (Montreal, Canada) (1991). He is Full Professor of Veterinary Pharmacology (since 1997), Director of the Center of Veterinary Research and Director of the Science and Technology Center from the Argentina National Council of Research (CONICET) at Tandil. Since 1992 he acted as Scientific Director of the research program on "Pharmacology of antiparasitic drugs in ruminants", which has received financial support from several national/international agencies. An important number of Ph.D. students and Fellowship recipients have received their formation in Veterinary Pharmacology and Parasitology under Dr. Lanusse?s supervision.
Professor Lanusse is internationally recognized for his outstanding scientific contribution (he has received numerous scientific awards) to the integrated understanding of the plasma disposition kinetics, tissue distribution, biotransformation in the animal host and patterns of parasite influx/efflux/metabolism for different antiparasitic compounds in livestock animals. This pharmaco-parasitological knowledge applied to optimise parasite control in the presence of drug resistance, has been worldwide disseminated in over 200 peer-reviewed publications (and Book Chapters) in the most reputed Parasitology/Pharmacology Journals. Bibliometric indicators in Scopus: 3115 citations, h index: 30; Google Scholar: 3812 citations, h index: 34.
Prof. Carlos Lanusse Med Vet., Dr Cs Vet., Ph.D., Dip ECVPT
Laboratorio de Farmacolog?a, Centro de investigaci?n Veterinaria de Tandil (CIVETAN), CONICET-Universidad Nacional del Centro, Tandil, Argentina.
In view of the increasing concern for the development of resistance, the use of pharmacology-based information is critical to design successful strategies for the future of parasite control in livestock. The magnitude of the investment in chemicals to control helminth parasites in domestic animals reveals the need for further scientific research on how to maximize drug use. Integrated pharmaco-parasitological research approaches have greatly contributed to optimize drug activity. The assessment of the drug disposition in the host and the comprehension of the mechanisms of drug influx/efflux/detoxification in different target helminths, has signified a relevant progress on the understanding of the pharmacology of anthelmintic drugs in ruminant species. However, additional scientific knowledge on how to improve the use of available and novel molecules is required to avoid/delay resistance development. Different pharmacokinetic-based approaches to enhance parasite exposure and the use of combination of drugs from different chemical families have been proposed as valid strategies to delay the development of anthelmintic resistance. The limited available information on the potential additive and/or synergistic effects occurring after co-administration of two (or more) drugs with different mode of action is unclear. The occurrence of potential pharmacokinetic and/or pharmacodynamic interactions between drug components highlights the need of deeper and integrated research to identify the advantages/disadvantages of the use of combined drug preparations. The data summarized in this 2015 WAAVP Keynote presentation emphasizes on how the use of pharmacology-based information may be critical to design successful strategies for the future of parasite control in ruminants, including significant issues needed to secure/extend the lifespan of the recently available anthelmintic molecules.